Acceptable safe performance enhancement without the use of steroids

In an effort to identify potential avenues of performance enhancement all the while using new drug regulations as a precipice I have potentially identified a naturally occurring amino acid which has been proven to produce stated desired results.

In 1988 a study by Gaffney and Cunningham (1) using Timeform ratings as an indicator investigated heritability of racing performance between 1952 and 1977. They reported a strong genetic performance and a “steady genetic gain of 1% per year” yet discovered “winning times had not improved during the last 50 years for classic races”. This was described by W. G. Hill (2) (1988) as “Cunningham’s Paradox”, he asked the question of “have horse breeders reached the limit of achievement of racehorses”. Cunningham (3) suggested that the “physiological limit might have been reached, for example, for dealing with lactic acid build up in the muscle during performance”.

Every movement of a muscle a horse makes requires energy, whether sprinting 7 furlongs or batting an eyelash energy is required. Their body produces that energy through the use of ATP (adenosine trihosphate). This energy is released when ATP is split into ADP (adenosine diphosphate) and P (phosphate). The human body, for example, has a very limited supply of ATP only enough to store fuel for about 3 to 5 seconds of work. Our bodies then “borrow” a phosphate group from another substance called PCr (phosphocreatine) and combined it with ADP. ADP + P = ATP.

Herein lays the potential answer to “Cunningham’s Paradox” whereby if genetics have reached their maximum capabilities could supplementation derived from a naturally occurring source thereby negating potential side effects substantially increase output and performance.

Creatine is a naturally occurring acid synthesized from lysine, argentine and methionine, in the liver, pancreas and kidneys. Muscles take up the majority of the creatine found in the body it is there that it is converted into phosphocreatine which is necessary (as stated earlier) for ATP production. Research shows that taking creatine supplements can increase muscle creatine by 20 to 30%. Increasing the amount of creatine found in the muscle also increases the amount of phosphocreatine, which aids in producing greater amounts of energy. This is because phosphocreatine is the limiting factor in energy production in high intensity anaerobic exercise. Numerous studies have identified the amino acid as producing substantial results in the performance of anaerobic events as well as increasing lean body mass, such as:

In 1997 a double blind study by Prevost, Nelson and Morris (4) supplemented with 18.75 g/day of creatine prior to high-intensity intermittent work to exhaustion, and then 2.25 g/day during testing “found that creatine supplements significantly delayed the onset of muscle fatigue in endurance athletes by boosting their lactate thresholds”.

Another double blind study in 1997 conducted by Bosco and others (5) provided 20 g/day to qualified sprinters who performed intensive treadmill running until exhaustion. They determined “creatine supplementation increased performance sprinting performance by 13%”.
A 2000 study by Mehlberg (6) stated “sprinters who loaded with creatine (25 grams for 5 days) significantly increased their peak and average power output compared to a group taking an inactive placebo”.

The Mayo Clinic (7) graded the supplement an “A” stating “several high-quality studies have shown an increase in muscle mass, lean body mass and strength”.

To my knowledge no study has been reported regarding the usage of creatine in equine athletes, however a 2001 study by Mc Farlane, Heigenhauser, D G McDonald (8) using fingerling rainbow trout which were “supplemented with equal amounts of creatine (Cr) by two routes: dietary (12.5 mg Cr per g food); or intraperitoneal injection (0.5 mg Cr per g fish). Endurance in a fixed velocity sprint test (at a speed of 7 BL s(-1)), and resting levels of white muscle metabolites (total creatine [a measure of free creatine plus phosphocreatine (PCr), ATP, lactate and glycogen] were assessed following 7 days of supplementation and compared to controls. It was determined that resting muscle glycogen was elevated in creatine-supplemented fish. Higher muscle glycogen corresponded to significantly greater endurance in creatine-supplemented fish”.
Obviously scientific and field testing on Thoroughbreds must occur before and absolute answer to “Cunningham’s Paradox” can be pronounced. However that being said overwhelming evidence must lead one to consider that creatine potentially is a naturally occurring, safe, legal and effective alternative to steroids.

REFERENCES:
(1) Gaffney, B and E. P. Cunningham, 1988. Nature 332: 722-724
(2) Hill, W. G. 1988. Nature 332: 722-724
(3) Gaffney, B and E. P. Cunningham, 1988. Nature 332: 722-724
(4) Prevost, M.C., Nelson A.G., Morris G.S., 1997. Research Quarterly for Exercise and Sport 68: 233-140
(5) Bosco, C. and others, 1997. International Journal of Sports Medicine 18: 369-372
(6) Mehlberg, D. 2000. Healthlink, Medical College of Wisconsin
(7) MayoClinic.com, 2008. Drugs and Supplements: Creatine
(8) Mc Farlane, Heigenhauser, D G McDonald, 2001. Comp Biochem Physiol A Mol Integr Physiol. 2001 Nov ;130 (4):857-66

Want a Safe Natural way to a Stronger, Faster, more Durable Race Horse then you need Protein

Probably the most misunderstood aspect of a horse’s diet protein is made up of long chain branch amino acids the building blocks of bones, muscles, and virtually all of the body's soft tissues, for growth and repair.

Essential Part of a Horse’s Diet

This makes protein an essential part of the diet as the horse continually uses protein either to build new tissues, as in growth, or to repair worn out tissues. Protein is the main constituent of the organs (such as liver, heart, kidneys, etc) and tissues (such as muscle, tendons, ligaments, cartilage) and most of the bone matrix which comprises 20% of bone is composed of protein. Protein is required to develop muscling, and most body functions require protein in many different forms.

The Power of Protein in Recovery in Race Horses

An Endocrinology and Metabolism study conducted at Copenhagen Muscle Research Centre, Copenhagen N, Denmark found the following results: 

Branched-chain amino acids (BCAA) or a placebo was given to seven subjects during 1 h of ergometer cycle exercise and a 2-h recovery period. Intake of BCAA did not influence the rate of exchange of the aromatic amino acids, tyrosine and phenylalanine, in the legs during exercise or the increase in their concentration in muscle. 

The increase was ~30% in both conditions. On the other hand, in the recovery period after exercise, a faster decrease in the muscle concentration of aromatic amino acids was found in the BCAA experiment (46% compared with 25% in the placebo condition).

There was also a tendency to a smaller release (an average of 32%) of these amino acids from the legs during the 2-h recovery. The results suggest that BCAA have a protein-sparing effect during the recovery after exercise, either that protein synthesis has been stimulated and/or protein degradation has decreased, but the data during exercise are too variable to make any conclusions about the effects during exercise. The effect in the recovery period does not seem to be mediated by insulin (Blomstrand, Saltin).

Faster Recovery = Faster, Stronger Horse

Steroids do not directly build muscle what they do however is decrease recovery time and thereby increase the ability to train and eat. The end result being increased muscle mass, increased strength and conversely increased speed. 

Not all Protein is Good / Useful Protein 

Normally a feed's protein level is determined by looking at the percentage value on the feed tag under "crude protein." But the crude protein numbers do not really reflect either a protein's overall quality (which can be determined only by the amino acid profile), or the amount of protein from that feed a horse can digest and use. 

Nitrogen Content

The crude protein value is based on the overall nitrogen content of a feed, and not all of the nitrogen in a feed sample is necessarily protein-bound. Nitrogen also might be found in purines, creatinine, ammonium salts, and nucleic acids, all of which might be in a feed sample. As such you are unsure as to the usefulness of the information when determining the proper amount of protein to supplement your race horse. 

Need Supplementation or Essential Amino Acids

The dietary requirements of race horses are not only a matter of providing a sufficient quantity of protein, the quality of protein is very important. Proteins are made of approximately 20 amino acids in varying combinations. 

Horses can only make about half of these amino acids and must therefore be supplied with the ones they cannot make. These are called "essential" amino acids. 

Quality Supplementation is the Key

Protein quality is determined by the proportions of essential amino acids making up the protein. Thereby all supplements administered to the horse should be produced in an FDA approved lab and graded as for human consumption. Otherwise the product may have little or no standards of quality and may actually cause more harm than good.